KMID : 1101720170210030001
|
|
Physical Activity and Nutrition 2017 Volume.21 No. 3 p.1 ~ p.10
|
|
The effects of downhill and uphill exercise training on osteogenesis-related factors in ovariectomy-induced bone loss
|
|
Kang Yun-Seok
Kim Chun-Ho Kim Jeong-Seok
|
|
Abstract
|
|
|
Purpose: Recent evidence suggests that regular exercise training plays a decisive role in maintaining homeostasis and promoting muscle and skeletal formation. However, the effect of downhill exercise training on osteogenesis-related factors is not well understood.
Methods: Thus, we investigated the effect of uphill and downhill training on ovariectomy (OVX)-induced bone loss. After ovary removal, the exercise method performed included uphill (16 m/min, +15¡Æ) and downhill training (16 m/min, ?15¡Æ) for 60 min/day and 5 days/week, respectively, for 8 weeks.
Results: Our results showed that both uphill and downhill training significantly decreased the body weight, total cholesterol, and creatine kinase (CK) levels in the context of OVX-induced bone loss. On the contrary, levels of an osteogenesis indicator, osteocalcin and alkaline phosphatase were elevated. Consequently, the uphill and downhill training reduced OVX- induced bone loss in the distal femoral metaphysis. Likewise, the bone microstructure in OVX-induced bone loss was enhanced upon training. In particular, the inhibition of RANKL-induced osteoclast formation and osteoclast-specific gene expression improved upon downhill training compared to uphill training.
Conclusion: These results suggest that the uphill and downhill exercise types appeared to positively affect the expression of osteogenesis-related factors along with bone density and microstructure. Particularly, the downhill training has more beneficial effects on the maintenance of homeostasis during bone formation.
|
|
KEYWORD
|
|
Ovariectomized rat, Bone formation, Osteogenesis, Bone mineral density, Trabecular bone
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|